- ◎略歴
- 東北大学薬学部卒業
東北大学大学院薬学研究科博士課程修了
東北大学歯学部助手
ストラスブール・メーレル国際研究センター研究員
パリ第11大学INSERM U200研究員
東日本学園大学（現・北海道医療大学）薬学部助教授
北海道医療大学薬学部教授
いわき明星大学（現・医療創生大学）薬学部特任教授
医療創生大学健康医療科学部特任教授 - ◎担当授業科目
- 健康医療科学部：人体の機能Ⅰ・Ⅱ、薬理学
薬学部：治療系実習（薬理学） - ◎専攻研究分野
- 薬理学
- ◎主な研究業績
- 【主な原著論文】
- Kimyo T., Machida T., Iizuka K., Minami M. and Hirafuji M.: Noradrenaline increases intracellular Cα2+ concentration in epithelial cells via α2-adrenoceptors in isolated mouse ileal crypts. J. Pharmacol. Sci. 148, 337-341, 2022.
- Machida M., Machida T., Kikuchi M., Shimizu A., Ida S., Tawaraya Y., Kato R., Haramaki K., Yama K., Shiga S., Hirafuji M. and Iizuka K.: Methotrexate mediates the integrity of intestinal stem cells partly through nitric oxide-dependent Wnt/β-catenin signaling in methotrexate-induced rat ileal mucositis. J. Pharmacol. Sci. 148, 281-285, 2022.
- Kamiya A., Machida T., Hirano M., Machida M., Shiga S., Hamaue N., Hirafuji M. and Iizuka K.: Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury. J. Pharmacol. Sci. 147, 251-259, 2021.
- Machida T., Tanaka A., Kobayashi M., Imai K., Hirafuji, M. and Iizuka K.: Methotrexate induces hyperplasia of enterochromaffin cells in mouse jejunum. BPB Reports 4, 112-115, 2021.
- Machida T., Endo T.H., Oyoshi R., Yutani M., Machida M., Shiga S., Murakami H., Hiraide S., Hirafuji M. and Iizuka K.: Abnormal Pressure Stress Reduces Interleukin-1β-Induced Cyclooxygenase-2 Expression in Cultured Rat Vascular Smooth Muscle Cells. Biol. Pharm. Bull. 44, 853-860, 2021.
- Machida T., Inotani A., Shiga S., Kon S., Yanada T., Kobayashi H., Hamaue N., Hirafuji M. and Iizuka K.: Role of nitric oxide in the change of 5-hydroxytryptamine synthesis in the intestine by a consecutive administration of methotrexate to rats.Pharmacology 105, 723-728, 2020.
- Kikuchi K., Hamaue N., Machida T., Iizuka K., Minami M. and Hirafuji, M.: Effects of nafamostat mesilate on 5-hydroxytryptamine release from isolated ileal tissues induced by anti-cancer drugs in rats. Biomed. Res. 41, 253-257, 2020.
- Shiga S., Machida T., Yanada T., Machida M., Hirafuji M. and Iizuka K.: The role of nitric oxide in small intestine differs between a single and a consecutive administration of methotrexate to rats. J. Pharmacol. Sci. 143, 30-38, 2020.
- Endo T., Samokhvalov V., Darwesh A., Khey K.M.W., El-Sherbeni A.A., Ei-Kadi A.O.S., Machida T., Hirafuji M., Seubert J.M.: DHA and 19,20-EDP induce lysosomal-proteolytic-dependent cytotoxicity through de novo ceramide production in H9c2 cells with a glycolytic profile. Cell Death Discov. 5, 116-126, 2019.
- Takano Y., Hirano M., Machida T., Obara Y., Hamaue N., Fujita K., Taniguchi M., Endo T., Shiga S., Machida M., Iizuka K. and Hirafuji M.: Nitric oxide plays a critical role in methotrexate-induced hyperplasia of enterochromaffin cells containing 5-hydroxytryptamine in rat small intestine. J. Pharmacol. Sci. 141, 32-40, 2019.
- Machida M., Shiga S., Machida T., Ohno M., Iizuka K. and Hirafuji M.: Potentiation of glucagon-like peptide-2 dynamics by methotrexate administration in rat small intestine. Biol. Pharm. Bull. 42, 1733-1740, 2019.
- Obara, Y., Machida, T., Takano, Y., Shiga, S., Hamaue, N., Iizuka, K. and Hirafuji, M.: Cisplatin increases the number of enterochromaffin cells containing substance P in rat intestine. Naunyn-Schmiedeberg's Arch. Pharmacol. 391, 847-858, 2018.
- Machida, T., Onoguchi, A., Iizuka, K., Ishibashi, S., Yutani, M. and Hirafuji, M.: Effect of docosahexaenoic acid on voltage-independent Ca2+ entry pathways in cultured vascular smooth muscle cells stimulated with 5-hydroxytryptamine. Biol. Pharm. Bull. 40, 916-921, 2017.
- Machida, T. Takano, Y., Iizuka, K., Machida, M. and Hirafuji, M.: Methotrexate causes acute hyperplasia of enterochromaffin cells containing substance P in the intestinal mucosa of rats. J. Pharmacol. Sci. 133, 190-193, 2017.
【主な総説】- Machida, T., Matamura, R., Iizuka, K. and Hirafuji, M.: Cellular function and signaling pathways of vascular smooth muscle cells modulated by sphingosine 1-phosphate. J. Pharmacol. Sci. 132, 211-217, 2016.
- Iizuka, K., Machida, T. and Hirafuji, M.: Skeletal muscle is an endocrine organ. J. Pharmacol. Sci. 125, 125-131, 2014.
- Machida, T., Iizuka, K. and Hirafuji, M.: 5-Hydroxytryptamine and its receptors in systemic vascular walls. Biol. Pharm. Bull. 36(9), 1416-1419, 2013.
【主な著書】- 平藤雅彦: 詳解 薬理学、分担執筆（315-338頁、401-432頁）、廣川書店（全662頁）、2015．
- 森田憲輝、沖田孝一、飯塚健治、平藤雅彦: 進化する運動科学の研究最前線、分担執筆（83-91頁）、株式会社NTS(全440頁)、2014．
- 平藤雅彦：パートナー薬理学（改定第2版）、分担執筆(221-252頁)、南江堂（東京）（全482頁）、2013．
- ◎主な学会活動
- 日本薬理学会（永年会員）
- ◎その他
- 北海道医療大学名誉教授