- ◎略歴
1999年 東京理科大学・基礎工学部 卒業 2004年 東京理科大学大学院・基礎工学研究科 博士後期課程修了 博士（工学） 2004年～2009年 東京理科大学・基礎工学部 助手・助教 2008年～2009年 東京理科大学・総合研究機構（ポリスケールテクノロジー研究センター） 兼任 2009年～2021年 岩手医科大学・薬学部 助手・助教 2021年～現在 医療創生大学・薬学部 准教授 - ◎担当授業科目
- 衛生化学、環境衛生学、放射薬品学、公衆衛生学、薬品安全性学、臨床栄養学、基礎数学演習１、数学、食品の科学、地球環境の科学、ファーマドリル５、ファーマドリルファイナル（衛生）、健康と環境要説、衛生系実習、自然科学実習入門（衛生）、イグナイト教育３、卒業研究A・B
- ◎専攻研究分野
- 衛生薬学、環境衛生学、分子生物学、腎臓病学
- ◎主な研究業績
- 原著論文
- Sei Yonezawa, Yasushi Kawasaki, Yasuhiro Natori, Akinori Sugiyama, Improvement of LXR-mediated lipid metabolism in nephrotic model kidney accompanied by suppression of inflammation and fibrosis. Biochem. Biophys. Res. Commun., 666, 122-127, 2023
- Masahiro Yamashita, Miyuki Niisato, Yasushi Kawasaki, Sinem Karaman, Marius R. Robciuc, Yuji Shibata, Yoji Ishida, Ryosuke Nishio, Tomoyuki Masuda, Tamotsu Sugai, Masao Ono, Rubin M. Tuder, Kari Alitalo, Kohei Yamauchi, VEGF-C/VEGFR-3 signalling in macrophages ameliorates acute lung injury.. Eur. Respir. J. 59, 2100880 (Online), 2022
- Sei Yonezawa, Mizuho Abe, Yasushi Kawasaki, Yasuhiro Natori and Akinori Sugiyama, Each liver X receptor (LXR) type has a different purpose in different situations. Biochem biophys res commun., 508, 92-96, 2019
- Masahiro Yamashita, Masahito Ogasawara, Yasushi Kawasaki, Miyuki Niisato, Heisuke Saito, Shuya Kasai, Chihaya Maesawa, Makoto Maemondo and Kohei Yamauchi, Deficiency of protein-L-isoaspartate (D-aspartate) O-methyl-transferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma. Oncotarget, 9,13287-13300, 2018
- Nobutaka Ogasawara, Tamami Kudo, Masaki Sato, Yasushi Kawasaki, Sei Yonezawa, Satoru Takahashi, Yohei Miyagi, Yasuhiro Natori and Akinori Sugiyama, Reduction of Membrane Protein CRIM1 Decreases E-Cadherin and Increases Claudin-1 and MMPs, Enhancing the Migration and Invasion of Renal Carcinoma Cells. Biol pharm bull., 41, 604-611, 2018
- Yasushi Kawasaki, Eriko Yokobayashi, Kentaro Sakamoto, Eri Tenma, Haruka Takaki, Yuki Chiba, Tomomi Otashiro, Mai Ishihara, Sei Yonezawa, Akinori Sugiyama and, Yasuhiro Natori, Angiostatin prevents IL-1β-induced down-regulation of eNOS expression by inhibiting the NF-κB cascade. J. Phrm. Sci., 129, 200-204, 2015
- Yasushi Kawasaki, Naomi Asachi, Isamu Tamura, Takashi Komeno, Naoyuki Iida, Hirotada Akiyama, Akinori Sugiyama and Fumio Tashiro, Implication of histone H10-derived 17-kDa DNase in tamoxifen-induced apoptosis in aflatoxin B1-elicited rat hepatocellular carcinoma cells. JSM Mycotoxins, 64, 117-139, 2014
- Shigekazu Murakami, Satomi Chishima, Hisato Uemoto, Erina Sakamoto, Takashi Sato, Nobuyuki Kurabe, Yasushi Kawasaki, Tatsuhiro Shibata, Hirotada Akiyama, Fumio Tashiro, The male-specific factor Sry harbors an oncogenic function. Oncogene, 33, 2978-2986, 2014
- Hiroko Otsuka, Yoshitaka Gotoh, Takashi Komeno, Takahide Ono, Yasushi Kawasaki, Naoyuki Iida, Yoshio Shibagaki, Seisuke Hattori, Makoto Tomatsu, Hirotada Akiyama, Fumio Tashiro, Aralin, a type II ribosome-inactivating protein from Aralia elata, exhibits selective anticancer activity through the processed form of a 110-kDa high-density lipoprotein-binding protein: A promising anticancer drug., Biochem. Biophys. Res. Commun., 453, 117-123, 2014
- Yumiko Urano-Tashiro, Hironobu Sasaki, Mioko Sugawara-Kawasaki, Takeyuki Yamada, Akinori Sugiyama, Hirotada Akiyama, Yasushi Kawasaki and Fumio Tashiro, Implication of Akt-dependent PRP19α/14-3-3β/CDC5L complex formation in neuronal differentiation. J. Neurosci. Res., 88, 2787-2797, 2010
- Yasushi Kawasaki, Naomi Adachi, Takashi Komeno, Isamu Tamura, Kazuko Inoue, Akinori Sugiyama and Fumio Tashiro, Possible involvement of chymotrypsin-like proteases in generation of 17-kDa histone H1 DNase during apoptosis. Res. Commun. Biochem. Cell Mol. &Biol., 14, 1-4, 2009
- Yasushi Kawasaki, Yoshitaka Gotoh, Kimikazu Tokuzen, Masao Kamimura, Takashi Komeno, Makoto Tomatsu, Risa Todoroki, Yukio Nagasaki, Kohei Soga and Fumio Tashiro, Selective tumor imaging by a novel tumor specific aralin-infrared-to-visible phosphor conjugate. J. Physics Conf. Series, (Proceeding), 191, 1-4, 2009
- Yuko Komiya, Nobuya Kurabe, Kumiko Katagiri, Makiko Ogawa, Akinori Sugiyama, Yasushi Kawasaki and Fumio Tashiro, A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis. J. Biol. Chem. 283, 18753-18764, 2008
- Yasushi Kawasaki, Tomio Yamazaki, Risa Todoroki, Noriyuki Sakamura, Yoshitaka Gotou, Yuko Komiya, Nobuya Kurabe, Naomi Adashi, Shigetoshi Miura, Fumio Tashiro, Possible involvement of CD133 in the appearance of cancer stem cells in hepatoma cells. Mycotoxins, 58, 89-96, 2008
- Takuto Matsui, Shinsuke Nishimura, Kenichi Kijima, Yasushi Kawasaki, Fumio Tashiro and Shigetoshi Miura, Crystallization and preliminary X-ray diffraction data of the rat histone H10 globular domain., Acta Cryst., 63, 403-405, 2007
- Nobuya Kurabe, Kumiko Katagiri, Yuko Komiya, Ryosuke Ito, Akinori Sugiyama, Yasushi Kawasaki and Fumio Tashiro, Deregulated expression of a novel component of TFTC/STAGAhistone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma:possible implication for the oncogenic potential of c-Myc. Oncogene, 26, 5626-5634, 2007
- Yasushi Kawasaki, Naomi Adacni, Tomio Yamazaki, Risa Todoroki, Yoshitaka Gotou, Yuko Komiya, Nobuya Kurabe, Kiyomitsu Nemoto, Masakuni Degawa, Shigetoshi Miura and Fumio Tashiro, Cancer stem cells in aflatoxin B1-induced rat hepatocellular carcinoma K2 cells. Mycotoxins, 57, 87-93, 2007
- Yumiko Urano, Masayuki Iiduka, Akinori Sugiyama, Hirotada Akiyama, Kouji Uzawa, Gaku Matsumoto, Yasushi Kawasaki and Fumio Tashiro, Involvement of the mouse Prp19 gene in neuronal/astroglial cell fate decisions. J. Biol. Chem., 281, 7498-7514, 2006
- Yuko Komiya, Ryuji Sakumoto, Nobyuya Kurabe, Tomokazu Oshiki, Akinori Sugiyama, Yasushi Kawasaki and Fumio Tashiro, Identification of a novel 14-3-3β binding partner and its functional analysis in aflatoxin B1-induced rat hepatoma K2 cells. Mycotoxins, 55, 107-110, 2005
- Nobuya Kurabe, Yuko Komiya, Seiichi Mochizuki, Kumiko Katagiri, Akinori Sugiyama, Yasushi Kawasaki and Fumio Tashiro, Deregulated expression of a novel gene, NC33, in aflatoxin B1-induced rat hepatocellular carcinoma K2 cells. Mycotoxins, 55, 111-116, 2005
- Makoto Tomatsu, Toshiya Kondo, Takafumi Yoshikawa, Takashi Komeno, Naomi Adachi, Yasushi Kawasaki, Akira Ikuta and Fumio Tashiro, An apoptotic inducer, aralin, is a novel type II ribosome-inactivating protein from Aralia elata. Biol. Chem. 385, 819-827, 2004
- Shinya Nakamura, Hiroki Kodama, Yasushi Kawasaki, Akinori Sugiyama, Takuro Matsui, Akira Tsugita and Tashiro, F., A novel endonuclease originated from histone H1 implicated in apoptosis. Res. Commun. Biochem. Cell Mol. &Biol., 3, 3-20, 1999
総説- Yasushi Kawasaki, Akinori Sugiyama and Fumio Tashiro, Molecular mechanisms of aflatoxin B1 hepatocarcinogenesis. Mycotoxins, 55, 149-153, 2005
- ◎主な学会活動
- 日本薬学会、日本マイコトキシン学会
- ◎その他
- 【受賞等】
- 平成26年度日本マイコトキシン学会、論文賞
【その他】- 2020年9月～ いわき市環境審議会委員